Mathematical Modeling in Cell Biomechanics: Myofibrils Contractile Activity
نویسندگان
چکیده
منابع مشابه
Induction of contractile activity by rigor complexes in myofibrils.
The relation between ATPase rate and substrate concentration was investigated for myofibrils with varying amounts of added BMM. There was a biphasic, 3 to 5-fold increase in ATPase in the absence of Ca*. In the absence of added BMM, the peak activity occurred at $ 0.1 mM MgATP. With increasing concentrations of BMM, the position and magnitude of the ATPase peak shifted to larger substrate conce...
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The incorporation of newly synthesized protein into myofibrils has been examined in a cell-free system. Myofibrils were added to a reticulocyte lysate after the in vitro translation of muscle-specific poly(A)+RNA. Only a small number of the many synthesized proteins were found to associate with the exogenously added myofibrils. These proteins were all identified as sarcomeric components and had...
متن کاملPosttranslational Incorporation of Contractile Proteins into Myofibrils m a Cell-free System
The incorporation of newly synthesized protein into myofibrils has been examined in a cell-free system. Myofibrils were added to a reticulocyte lysate after the in vitro translation of muscle-specific poly(A)+RNA. Only a small number of the many synthesized proteins were found to associate with the exogenously added myofibrils. These proteins were all identified as sarcomeric components and had...
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Characterizing the contractile function of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) is key for advancing their utility for cellular disease models, promoting cell based heart repair, or developing novel pharmacological interventions targeting cardiac diseases. The aim of the present study was to understand whether steady-state and kinetic force parameters of β-myosin heavy ...
متن کاملDimethyl sulphoxide enhances the effects of P(i) in myofibrils and inhibits the activity of rabbit skeletal muscle contractile proteins.
In the catalytic cycle of skeletal muscle, myosin alternates between strongly and weakly bound cross-bridges, with the latter contributing little to sustained tension. Here we describe the action of DMSO, an organic solvent that appears to increase the population of weakly bound cross-bridges that accumulate after the binding of ATP, but before P(i) release. DMSO (5-30%, v/v) reversibly inhibit...
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ژورنال
عنوان ژورنال: Applied Mathematics
سال: 2015
ISSN: 2152-7385,2152-7393
DOI: 10.4236/am.2015.67103